The benefits of Exercise and sleep disorders before surgery

Exercise can protect muscles and nerves from damage caused by blood flow recovery after injury or surgery.

Zhen Yan, PhD, an expert on the benefits of mobile UVA sports, together with his team is working to better understand how the body damaged by restoration of blood flow--known as ischemia-reperfusion injury-and to find ways to improve the outcome for people who experienced it, including patient surgery and trauma. Their new findings show that exercise pre-injury has great benefits in terms of keeping the muscles and nerves.

The benefits of Exercise and sleep disorders before surgery


 "Trained Rats with exercise has a much better recovery, evidenced by fewer nerve damage, less muscle damage and reduced contractile function (on) immediately after the injury and a few days later, " clear Yan, Director of the center of the Muscle the framework. Research at UVA Robert m. Berne Cardiovascular Research Center.

Due to damage caused by reperfusion injury, doctors are now working to limit the amount of time blood flow is cut off to not more than 90 minutes.

 "There are some situations where you have to stop the bleeding for the saving of lives, " says Yan.

He added, "How's that we often do is to wear a tourniquet, to actually stop the circulation until the patient can be brought to the emergency room. But there is a problem there: we can not block it for too long. The networks will die. We had to restore the blood flow at some point, but it will cause reperfusion injury. That's where ironically.

In his latest research, Yan and his team use  "gene reporter " that he developed called MitoTimer to understand the effect of reperfusion injury on muscles and nerves. Reporter gene allows them to measure the amount of  "oxidative stress " to the power plants of cells, mitochondria, when blood flow is restored.

They found that exercise reduces the injury obviously pre-damage to the muscles and nerves, but it does not significantly reduce the amount of oxidative stress.  "We know exercise makes your muscles and nerves are harder, " says Yan.  "Protection is very clear."

While the protection mechanism is not yet understood, the study of Yan had previously been explained what happens to muscle cells when blood flow is restored. He likened it with the cable disconnected from the circuit board. He even identified a compound that helps protect the mitochondria in the circuit board it.


 "With these treatments, we found the circuit board, the structure of which is called the neuromuscular junction where the nerves are physically connected by muscle to control contraction, " said.  "Cable is still connected. It functions normally. Therefore, her recovery much faster. "these drugs could potentially prevent nerve damage caused by the recovery of blood flow and speed up the recovery of the patient. (But it is clear that the practice of sport, achieve this through a different mechanism.)

More work needs to be done before the drug can be used in humans, but Yan think that promising discoveries. Especially for professions which are full of risks was hurt physically.

"Simple things are wont to do is wrap the limb to block circulation, to block bleeding, " said.  "But at a certain point, you have to rebuild the circulation, and the approach we can offer a way to minimize collateral damage and get better results."

Yan, of the Division of cardiovascular medicine, UVA, plan to continue his investigations into the drug and reperfusion injury against in General as part of a larger research about how exercise is beneficial to the health of cells and man.

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As with any sport, OSA also turned out to be beneficial for smooth operation. According to a study whose results were announced in the official medical journal of the American Society of Anesthesiologists (ASA), patients with OSA who was diagnosed and treated for the condition before the operation, have the possibility to experience minimum complications serious cardiovascular like stopping the heart or shock.

 "OSA is a common disorder that affects millions and is associated with an increased risk of the complications of surgery, but his condition is often not recognized, " says Thomas Mutter, m.d., the lead author, Department of anesthesia and medicine, University of perioperatif Winnipeg, Manitoba, Canada.

 "As much as 25 percent of surgical patients may be suffering from OSA, but most of these patients are not treated or do not know they have the disorder."

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